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Nevertheless, due to underenrollment, delayed medication administration, insufficient sample size, and inadequate dosage, the impact of CBZ to prevent seizures or DT is still uncertain and effectiveness compared to BDZ has not been verified.81 A retrospective analysis of over 700 patients comparing CBZ to valproate (VPA) found VPA to offer some benefits compared to CBZ, such as favorable tolerability and shorter duration of treatment

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Conversely, the antioxidant marker asprosin exhibited significantly higher concentrations in both plasma and amniotic fluid samples within the T21 group when compared to euploid pregnancies

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